The Impact of Single Nucleotide Polymorphisms on Human Aldehyde Oxidase
نویسندگان
چکیده
منابع مشابه
Correction to "The Impact of Single Nucleotide Polymorphisms on Human Aldehyde Oxidase".
Aldehyde oxidase (AO) is a complex molybdo-flavoprotein that belongs to the xanthine oxidase family. AO is active as a homodimer, and each 150-kDa monomer binds two distinct [2Fe2S] clusters, FAD, and the molybdenum cofactor. AO has an important role in the metabolism of drugs based on its broad substrate specificity oxidizing aromatic aza-heterocycles, for example, N(1)-methylnicotinamide and ...
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Aldehyde oxidase (AOX1) is an enzyme with broad substrate specificity, catalyzing the oxidation of a wide range of endogenous and exogenous aldehydes as well as N-heterocyclic aromatic compounds. In humans, the enzyme's role in phase I drug metabolism has been established and its importance is now emerging. However, the true physiologic function of AOX1 in mammals is still unknown. Further, num...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2012
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.111.043828